Preparing Your Family History Book for Publication

Preparing Your Family History Book for Publication After years of carefully researching and assembling a family history, many genealogists find that they want to make their work available to others. Family history means a lot more when its shared. Whether you want to print a few copies for family members or sell your book to the public-at-large, todays technology makes self-publishing a fairly easy process. How Much Will It Cost? To estimate publishing costs, you will need to consult with local quick-copy centers or book printers. Obtain bids for the publishing job from at least three companies since prices vary greatly. Before you can ask a printer to bid on your project, however, you need to know three vital facts about your manuscript: Exactly how many pages are in your manuscript. You should take the finished manuscript with you, including mock-ups of picture pages, introductory pages, and appendixes.Approximately how many books you want to be printed. If you want to print under 200 copies, expect most book publishers to turn you down and send you to a quick-copy center. Most commercial printers prefer a run of at least 500 books. There are a few short-run and print-on-demand publishers who specialize in family histories, however, who are able to print in quantities as small as a single book.What kind of book features you want. Think about the paper type/quality, print size and style, number of photos, and binding. All of these will factor into the cost of printing your book. Spend some time browsing through family histories at the library to get some ideas on what you want before heading to the printers. Design Considerations LayoutThe layout should be appealing to the readers eye. For example, small print across the entire width of a page is too hard for the normal eye to read comfortably. Use a larger typeface and normal margin widths, or prepare your final text in two columns. You can align your text on both sides (justify) or only on the left side as in this book. The title page and table of contents are always on the right-hand page - never on the left. In most professional books, chapters also start on the right page. Printing Tip: Use high-quality 60 lb. acid-paper paper for copying or printing your family history book. Standard paper will discolor and become brittle within fifty years, and 20 lb. paper is too thin to print on both sides of the page. No matter how you space the text on the page, if you plan to do double-sided copying, be sure that the binding edge on each page is 1/4 inch wider than the outside edge. That means the left margin of the front of the page will be indented 1/4 extra, and the text on its flip side will have that extra indentation from the right margin. That way, when you hold the page up to the light, the blocks of text on both sides of the page match up with one another. PhotographsBe generous with photographs. People usually look at photographs in books before they read a word. Black-and-white pictures copy better than color ones and are a lot cheaper to copy as well. Photographs can be scattered throughout the text, or put in a picture section in the middle or back of the book. If scattered, however, photos should be used to illustrate the narration, not detract from it. Too many photos scattered haphazardly through the text can distract your readers, causing them to lose interest in the narration. If youre creating a digital version of your manuscript, be sure to scan the pictures at least at 300 dpi. Balance your selection of pictures to give equitable coverage to each family. Also, be sure you include short but adequate captions that identify each picture - people, place, and approximate date. If you don’t have the software, skills, or interest in doing it yourself, printers can scan your photos into digital format, and enlarge, reduce, and crop them to fit your layout. If you have a lot of pictures, this will add quite a bit to the cost of your book. Binding Options Printing or Publishing the Book Some publishers will print hard-bound family histories with no minimum order, but this usually increases the price per book. The advantage to this option is that family members can order their own copies when they wish, and you arent faced with purchasing books and storing them yourself.

15 Vital College Survival Tips

15 Vital College Survival Tips In this quick-read article you’ll find 15 college survival tips that get straight to the heart of the matter. We didn’t waste time with fluff tips or nonsense. Each one is serious business so let’s get to it. 1. Make Eating Right Exercising Habitual Yes, really. Eating right is going to work miracles all by itself because you’ll be running on all cylinders. Exercise will keep you in shape and balanced. Being healthy is really a good idea (who’d-uh thunk it?) and it helps you get the most out of your college experience. 2. Maintain Relationships with the Right Professors Don’t hesitate. From the get-go you need to be establishing relationships with the professors that matter most to you given your goals/focus. Don’t be creepy or in a hurry. Just approach them and let them know they’ll be seeing you around for the next few years and you would love to get to know them. That’s it. Then practice being a student they’re pleased with. It makes college life so much easier when you’re connected to the right people. 3. Know Your Major from Day One Don’t be indecisive. Make a decision and stick with it. Don’t spend a year or two bouncing around from one major to the next wasting time and money. If you’re too young to think about your future in a mature way, maybe you should wait before committing to college? At the end of the day it’s not necessary, but knowing your major from the start makes college much more rewarding. 4. Get Lame Classes Done First Regardless of your major there are a bunch of classes you need to take. Some are the fun classes while others are going to be hard or boring electives you’re not interested in. Don’t avoid them. Get them done with as early as possible so you can spend as much time as possible on the classes that matter to you most. 5. Realize that College is Temporary Don’t get so lost in the moment that you make decisions which could really harm you down the road. Like, maybe it’s not a good idea to post videos on the net of you doing illegal or ridiculous things. Especially if you plan on becoming a teacher or public official. I mean live it up, but don’t forget that college is just a temporary place and the real world awaits you. Also, because college is temporary you really don’t need to take it so seriously that you cause yourself physical or psychological harm. Get it, do your time, get your degree(s) and then move on. It’s that simple. 6. Cradle a Sense of Balance Relax. Find ways to keep yourself balanced and cradle them because they mean so much. Resistance training really helps. Take a yoga class. Do something to keep your mind and body centered so that you don’t get too swept up into things. 7. Be Strategic with Procrastination We all procrastinate, it’s fine. Just make sure you use it wisely. Mid-terms aren’t a good choice†¦jus’sayin. 8. Destroy Your Comfort Bubbles You’re going to survive college. One way to make sure you get the most of it, is to demolish your comfort bubbles and explore, experiment, travel and make yourself available to exquisite experiences. 9. Are You Ready to be a Parent? Seriously. Sex is awesome and there are TONS of young sexy people in college. The question is, are you prepared to be a mommy or daddy? If not, then you need to take sex a bit more seriously. 10. Don’t Avoid Class Difficulty Maybe that class sounds awesome, but on the first day you felt like it might be better to swim in razor blades and lemon juice. Hold on a minute, don’t be so quick to hop out of classes that you find challenging. These are known as character-builder classes. 11. Go to Class! We had to include this one because we understand how powerful propaganda can be. The more you see, read and hear â€Å"go to class!† the higher the chances are that you’ll go. These classes cost money and they are time in your life you’ll never get back so you better take them seriously. 12. Learn How to Take Proper Notes This isn’t high school. Take notes seriously. Clue: you don’t need to take a â€Å"how to take notes† class. 13. Learn to Chill at Test Time The more prepared you are the more relaxed you’ll be. Don’t let anxiety and fear gobble up tons of your mental energy. Instead, make sure you’re prepared and ready to rock when test time comes. 14. Focus on the Right Kind of Friends Don’t let idiots drag you down. Hang with people that can help you succeed and vice versa. 15. Go to Tons of Events Take advantage of as many school events as possible, because then you’ll meet tons of people and create for yourself tons of opportunities (relationships). So how about it folks? Do you agree these are the big hitter survival tips or what? Let us know what you do to survive.

Business peer review Essay Example | Topics and Well Written Essays - 500 words

Business peer review - Essay Example The labeling is clear and the table of content is functional. This improves the quality of the report. The author attempts to justify the study. He provides an appropriate background information about the problem. This way, he succeeds in explaining the relevance of the report by outlining the nature of the problem. Do the author’s recommendations seem to follow from the information he or she has presented? Are the recommendations based on sound reasoning, and are they clearly written with the intended audience in mind? The recommendations are consistent with his research findings. They strive to resolve the problem he alludes to in the first paragraphs. This way, he maintains coherence to the topical issue and the problem he introduced in the first paragraph. The writing style is clear and concise thus making the report both cohesive and coherent. He uses simple yet descriptive language. This enhances the quality of the paper since it targets a wider

Global Leadership Development Essay Example | Topics and Well Written Essays - 750 words

Global Leadership Development - Essay Example Wyman enumerates some of the traits that a global leader should possess(2007). He mentions that a global leader should foster growth on a global basis(Wyman, 2007). Moreover, it is essential that he understands the different cultures and must have language skills. Since most organizations now have offices and branches around the world, the global leader must be competent enough to deal with employees of different nationalities. They must be flexible enough to be able to relate with their employees with diverse ages, culture, behaviors, and beliefs. Wyman also stressed that global leaders must think beyond boundaries (2007). Furthermore, they must be able to manage people even if they do not deal with them face to face.Aside from understanding his employees, a global leader must also think the way his worldwide customers do. He must appreciate the needs and wants of his customers who come from various regions.The challenge surrounding the issue of finding global leaders is that some o f these leaders’ capabilities do not necessarily match â€Å"the current emerging business requirements† of their organizations(Wyman, 2007). Another key issue in global leadership development is how to fill the pipeline and identify employees who can work from a global perspective(Wyman, 2007). Organizations must develop the global leadership skills of their employees. Some developmental tools that companies may adopt are assigning them to different jobs, mentoring or coaching, offering international business travel, etc.xposing them to experiential or action learning assignments, introducing international cross-functional teams, giving short and long-term expat assignments, providing language and cross-cultural training and implementing a 360-degree feedback system (Callison, 2011). The challenge faced in this issue is that if these employees are not developed soon, there might be a shortage of leadership talent; thus, creating problems in meeting future business requirements (Wyman, 2007). The third issue confronting global leadership development is the management of the process of gathering relevant information on pote ntial leaders and making decisions on the new roles that will be given to them and the organizational support that will be provided them (Smith, 2007). According to Smith, there are three factors that will help manage the process, namely: 1) executive engagement and ownership; 2) process resonance and simplicity; and 3) the right tools (2007). The executive engagement and ownership means that all executives of the company should be supportive of the program for developing global leaders. Process resonance and simplicity suggests that talent management must be simple and must be aligned with the organizational culture. On the other hand, the right tools refer to the technology utilized in the management of data related to decisions pertaining to the future leaders. The challenge in this issue is top management’s all out support for the development of leaders within the organization. They should not be threatened by the existence of potential leaders and therefore must be willi ng to reinforce the development process of these future leaders.

Medicines and drugs Essay Example for Free

Medicines and drugs Essay A drug or medicine is a chemical that alters incoming sensory sensations, mood or emotions, or physiological state. Painkillers, hallucinogens and alcohols are examples of drugs and medicines that alter incoming sensory sensations. Prozac and alcohol alter mood or emotions Steroids, cigarettes and heart medicines alter physiological state, including consciousness, activity level or coordination. Drugs such as antiseptics, antibiotics and antivirals are infection fighters; hormones and vitamins affect body chemistry or metabolism; stimulants, depressants, analgesics and anesthetics affect the central nervous system and the brain. It is also important to understand that the human body has great natural healing processes; some drugs just increase the rate of natural healing. Also, there could be a placebo effect, it is when a pharmacologically inert substance that make seems to help because the person taking the substance was told that it would work. Placebo effect is examined by giving sugar pills to one group of tests patients, and real drugs to another group (when they are not aware of which they receive). B.1.2: Outline the stages involved in research, development and testing of new pharmaceutical products. This takes a very long time and costs a fortune, and is often controlled by the government. Before drugs are tested on humans, they must be testing on various animals (start with small animals and then go to bigger ones). The range of effective doses, the doses in which side-effects arise and the lethal doses have to be determined. There are 3 phases then; clinical trial; clinical evaluation (more in depth analysis); human studies with more evaluation, Very few drugs make it to the market, and the development would have cost a lot. Sometimes, things can still go wrong, like Thalidomide. It was given to pregnant women to treat morning sickness, but it cause deformities in babies! Now it is still used, but to treat skin sores. B.1.3. Describe the different methods of administering drugs * Oral: Very convenient. However, it might not be reliable as the rate of absorption depends on drug concentration, stomach content and pH value. As most is absorbed in the small intestines, so the drug must survive the gastric acid. Therefore it often lays in time release capsules. * Rectal: Good when drug cannot be taken orally due to vomiting or because the drug is pH sensitive. * Inhalation: Rapid, as there are loads of blood vessels in the lungs, and therefore a drug would have a reliable effect. Good for general anaesthesia, and asthma medicine. * Parental o Just below the skin; slower than for intravenous. Used often for dental injections o Into muscles; for large doses, or when immediate response is not needed (vaccines etc). o Intravenous; almost instantaneous, but cannot be undone when injected! Fatty lipids may bind some kinds of drugs, so the drugs wont leave the body so fast The half life of a drug is the time for half the dose in the body to be eliminated. B.1.4. Discuss the terms lethal dosage (LD50), tolerance and side effects. LD50 is the lethal dose for 50% of the population; and it varies a lot from drug to drug. When one is tolerant, then one has to take a larger dose in order to feel the wanted effects. Some people after often use of a drug becomes dependant on it; physically (they must have it to be able to function physically) or psychologically (they must have it to feel right). Tolerance doesnt necessarily mean that one gets used to the harmful effects. Sometimes it is hard to know the difference between main effect and side effect. A drug has many effects, and some patients benefit from a few of those effects; then those are the main effects, and all the other are side effects. Someone else, with another disease may benefit from other effects, and then those become the main effects. There are always harmful effects too. The risk : benefit ratio should also be considered. B.2.1. State and explain how excess acidity in the stomach can be reduced by the use of different bases. Bases, most often metal oxides, hydroxides, carbonates or hydrogen carbonates are used as antacids. These react with acid in the stomach to adjust the pH value. The purpose of gastric acid is to kill off bacteria, and help in digestion. However, over-eating or stress stimulates more production of acid, causing discomfort. The active ingredients tend to be; this react only with HCl: Magnesium Oxide: Magnesium Hydroxide: Aluminium Hydroxide: Calcium Carbonate: Sodium Hydrogen Carbonate: Magnesium Trisilicate: Some of the products; Carbon dioxide is a gas. So a foaming agent has to be added to prohibit excessive belching. Also alginates are used, to prevent acid reflux. If too much antacid is used, the stomach becomes too basic, and that hurts too; then more antacid might be wrongly taken. This leads to alkalosis. B.3.2. Describe the use of derivatives of salicylic acid as mild analgesics and compare the advantages and disadvantages of using aspirin and paracetamol (acetaminophen) Salicylic acid is used as an anti-pyretic (fever reducer) and mild analgesic (painkiller), but it is a strong acid and hurts the stomach and mouth; so variations of salicylic acid was used. One is Acetyl Salicylic Acid (ASA) or Aspirin, which has the benefits of salicylic acid and does not irritate so much due to the acetyl group. When ASA reacts with water, it becomes salicylic acid, and the by-product of ethanoic acid. GOOD: It is good for killing minor pain, reducing fever, acting as an anti-inflammatory agent and prevents abnormal blood clot. BAD: Upsets stomach and bleeding; allergy; accidental poisoning in infants and Reyes syndrome. Acetaminophen is also an anti-pyretic and analgesic. However it does not upset the stomach and is safe. However, overdose can still occur and lead to liver and brain damage. And it is not anti-inflammatory. Ibuprofen is like aspirin and cause fewer stomach problems. It is anti-inflammatory and is very safe. B.3.3. Compare the structures of morphine, codeine and the semi-synthetic opiate heroin. These are strong analgesics and are often called opiates, narcotics or narcotic analgesics. The major pain relieving substance originates from the opium poppy plant is sleep inducing and pain relieving. All three share the same skeleton. Remember the group C2H3O2 is called an acetyl group. B.3.4. Discuss the advantages and disadvantages of using morphine and its derivatives as strong analgesics. These affects: The Central Nervous System, the Eye and the Gastrointestinal tract (the digestive system) They are used as: Strong analgesics (severe pain from injury and chronic diseases); treatment of diarrhoea, relieve coughing. However they are very addictive and are rather replaced with something else. They also produce mood changes, drowsiness and mental clouding. Tolerance can arise by adaptation of the liver and neurons in the brain. Some people cant function without the drug, feeling restlessness, sweating, fever, chills, vomiting, aches etc due to abstinence of the drug. There is often severe psychological dependence too (one might feel extremely depressed).à ¯Ã‚ ¿Ã‚ ½ Short term effects: Sedation, stupor, pain relief, euphoria, reduced tension, worry, couching reflex. One might die of overdose. Long term effects: Loss of appetite, sterility, withdrawal illness, crime, diversion of energy. B.4.1. Describe the effects of depressants Tranquilizers, sedatives and hypnotics, which calm and relax; they slow down heart rate and breathing. Tranquilizers include alcohol, Valium and Librium and are weaker than the others. These relieve anxiety and tension. Sedatives: Barbituates that soothe distress without producing much sleep in small doses. Hypnotics: Like chloral hydrate. These induce sleep. Too much can lead to coma or teach. B.4.2. Discuss the social and physiological effects of the use and abuse of ethanol. Social effects: Major costs from alcohol are from sickness and death, as in hospital treatments and lost efficiency. Property crimes and crimes against people; drinking while driving. Physiological effects: Harmful to relationships, and may physically or emotionally harm others. One may lose control and develop dependence and tolerance. It increases blood pressure when drinking and nausea, sweating and anxiety as withdrawal of use. Short-term effects: CNS depressant reduces tension. It triggers Euphoria, Talkativeness, Dilation of blood vessels, Violent behaviours, Inertia, Coma, Death. Long term effects: Cirrhosis, liver cancer, coronary heart disease, high blood pressure, strokes, gastritis, low birth mass etc. Alcohol can be used for antiseptics such as mouthwashes. B.4.3. Describe and explain the techniques used for the detection of ethanol in the breath of in the blood or urine. Ethanol passes from the stomach into the blood and therefore it passes into the lungs and ethanol vapour is formed. The breathalyser test might involve a redox equation with potassium dichromate: as oxidizing agent. Color change: Red-Orange to Green The gas liquid chromatography works as follows: Small samples of gases and volatile liquids such ethanol are separated. These are pushed through a column using an unimportant gas, such as Nitrogen gas and different gases take different time to come to the detector, where concentration of gases are measured. Intoxilyzer, Infra-red spectroscopy: Infra-red energy make molecules vibrate. Different types of bonds absorb and vibrate at different infer-red frequencies. By measuring how much energy is not absorbed by the molecules, one can find the number of certain bonds in the molecules. B.4.4. Describe the synergistic effects of ethanol with other drugs. Alcohol is easily absorbed in the stomach, so drugs that can be dissolved in alcohol will be absorbed much quicker, and the dosage will seem higher as in normal conditions the liver removes a part of the drug. So performance of the drug is enhanced and may lead to devastating effects such as death, especially if alcohol is combined with barbituates. Alcohol with aspirin increases the risk of stomach bleeding. B.4.5 . List other commonly used depressants and describe their structures. Valium (diazepam) is a tranquilizer, Mogadon (Nitrazepam) is a hypnotic drug (used to control seizures and infantile spasms), Prozac (hydrochloride) is an anti-depressant drug used to treat mental depression. Diazepam and Nitrazepam have similar carbon skeletons meanwhile Prozac is different. B.5.1. List the physiological effects of stimulants. Stimulants are chemicals that stimulate the brain and the central nervous system. It is the opposite of a depressant. These increase alertness. Examples are amphetamine, nicotine and caffeine. B.5.2. Compare amphetamines and adrenaline They both derive from the phenylethylamine structure, and therefore look similar. Furthermore, amphetamines mimic the effects of adrenaline (they are sympathomimetic drugs), as they constrict arteries and thus increases sweat production. They increase heart rate, blood pressure, respiration and insomnia. Medical uses: Treat mild depression, narcolepsy and asthma. They use up the bodys reserve energy and can lead to a collapse. B.5.3 Discuss the short- and long-term effects of nicotine consumption. Tobacco is a source of nicotine which is a mild stimulant with a short lived effect. The response is followed by depression and thereby makes one pushed to use it more often. Short-term: Increase in heart-rate and blood pressure. It constricts blood vessels and therefore strains the heart. Nicotine also reduces urine output. Long term effects of nicotine: It stresses hard and may lead to heart diseases and blood clot; May lead to increase of fatty acids in the blood. Smoking leads to more carbon monoxide in the blood making the blood less able to carry blood. It also increases the gastric acid production and may lead to ulcer. Smoking causes: Cancer in lungs and mouth; heart and blood vessel disease; breathing difficulties and chronic bronchitis; air pollution; fires; bad teeth; insomnia. B.5.4. Describe the effects of caffeine and compare its structure with that of nicotine. Caffeine stimulates the respiratory system (more energy is available from respiration), so heart and brain gets more energy. So one becomes more alert, motivated and well-being. In small amounts in is rather harmless, but too much causes insomnia. One gets more urine as well. Caffeine leads to some tolerance but no physical addiction. It can be given to babies to help their breathing. It also constricts blood vessels and therefore helps against migraines. Both caffeine and nicotine contain a tertiary amine group. Caffeine has more of those though. B.6.1. Describe the historical development of penicillins. In 1928, Fleming accidentally saw that some types of fungi killed off a certain bacterium and started to try to isolate the fungi, but it was too hard to purify it. In 1940, Floray and Chain continued with penicillin testing and development, and in 1943 it was available clinically. The first penicillin was Penicillin G. However it was deactivated by stomach acid so it had to be injected. Acid resistance penicillins such as penicillin V was developed by modifying the side chains of the basic penicillin structure. Some bacteria could deactivate penicillin G by synthesising an enzyme, therefore one had to make other synthetic penicillins. 6-APA penicillin is inert, but an extra amino group H2N would activate it. B.6.2. Compare broad spectrum and narrow spectrum antibiotics A broad spectrum antibiotics is effective against a wide variety of bacteria. Examples are tetracyclines. Narrow ones are effective only against certain types of bacteria; most penicillins are narrow spectrum antibiotics. One often has to determine the bacterium before getting antibiotics, because a broad-spectrum one can kill beneficial bacteria and give discomfort. B.6.3. Explain how penicillins work and discuss the effects of modifying the side chain. The cell walls of some bacteria are composed of polysaccharides, and these layers are supported by cross-links. However, penicillins interfere with the formation of these links and therefore weaken the structure. The bacteria can easily burst. Animals cells dont have these cell walls and are therefore not affected. It is important to modify the side chain to work against bacteria have evolved and are able to break down certain types of penicillin. Side chains are also added to make the penicillin work (as for the 6-APA) and to survive the gastric acid (Penicillin G) B.6.4. Discuss and explain the effect over prescription of penicillins has, and the use of penicillins in animal feedstock Repeated use may lead to allergic reactions. They can also wipe out harmless and beneficial bacteria in the food canal, and harmful bacteria might eventually replace these. Bacteria can become resistant against certain antibiotics and then pass on their immunity. In feedstock: They are used to kill dangerous pathogens which may otherwise endanger humans and animals. They are also used to increase productivity. However, this increases the chances that bacteria might become resistant. B.7.1. State how viruses differ from bacteria Bacteria are relatively large single cell microorganism with DNA strands. Viruses are noncellular and are much smaller and are not living. They can only reproduce within a host cell. B.7.2. Describe the different ways in which antiviral drugs work * Block the transfer of genetic information * Control by inoculation, vaccines. * Block the enzyme activity in a host cell, so that the virus cant use it to replicate. B.7.3. Discuss the difficulties associated with solving the AIDS problem HIV molecules bind to proteins on T-type of white blood cells and hinder them from fighting infections by inactivating them. HIV virus is good at mutating and together with their similarities with human cells, it is very heard to treat with antiviral drugs and vaccines. B.8.1. Describe the importance of geometrical isomerism in drug action. Stereoisomers are isomers with the same molecular formula and the same structural formula, but different arrangement of atoms in space. Geoemetric isomers have different physical properties such as polarity, boiling point, and solubility etc. They may also undergo different t chemical reactions although their functional groups are identical. For example cisplatin is en effective anti-cancer drug (as it may enter the nucleus of a cancerous cell), but the trans-isomers is inactive in such purposes. B.8.2. Discuss the importance of chirality in drug action. Optical isomers differ from geometric isomers in two ways: * Optical isomers are chiral (asymmetric) * Optical isomers are non-superimposable mirror images of each other One optical isomer rotates the plane polarized light one direction, meanwhile its other isomer rotates it the other way. An equi-molar mixture of two enantiomers means a 50-50 ration and will not totate the plane of polarised light at all; this is a racemic mixture. Penicillin V is active, but its enantiomer is inactive. One enantiomer of Thalidomide could be used to treat morning sickness in pregnant women and was marketed as a racemix mixture, but its other enantiomer gave foetal deformities. B.8.3. Describe the use of chiral auxiliaries to form the desired enantiomer. It is very heard to separate racemic mixtures into separate enantiomers, as they have identical chemical properties in relation to non-chiral reagents. Instead, scientists use stereospecific synthesis to produce only one kind of enantiomer. Chiral auxiliaries are used to convert non-chiral molecules into a desired enantiomer by attching itself chemically to the non-chiral molecule so that only one type of enantiomer can be formed. After the procedure the auxiliary can be recycled. This is used when synthesising Taxol which isa drug effective against breast cancer. B.8.4. Explain the use of combinatorial chemistry to synthesise new drugs. This is when one creates lots of molecules and test them quickly for biological properties; one starts with a set of basic chemicals which are then combined in all possible combinations, and this allows a fast production of many different molecules, increasing the chance of finding better drugs. A library is a collection of compounds that are screened to determine their usefulness as a drug, using parallel synthesis (identical processes with many different molecules at the same time). B.9.1. Compare local and general anaesthetics in terms of their modes of action Local anaesthetics block the pain in specific areas when they are injected under the skin or used as a crà ¯Ã‚ ¿Ã‚ ½me. Examples are cocaine, procaine, benzococaine, lidocaine etc. These block local nerve transmissions and decrease blood supply to that area. Procaine and lidocaine do not affect the brain, meanwhile cocaine does. General anaesthetics affect the brain and produce unconsciousness. But it is easy to reverse the unconsciousness. Examples are nitrous oxide, diethyl ether, chloroform, cyclopropane and halothane. B.9.2. Compare the structures and effects of cocaine, procaine and lidocaine. All three have the benzene ring and the tertiary amine. Cocaine also stimulates the central nervous system. It constricts blood vessels which leads to high blood pressure, and cant be safely used. Although it doesnt produce withdrawal symptoms and tolerance, it produces a strong psychological addiction. An overdose suppresses heart and respiration. Cocaine has a very short half life as it is metabolized by the liver fast, and is poorly absorbed when taken orally. Procaine gives prolonged relief from pain which is good for surgery and dental procedures. It is non-toxic and non-irritant. Lidocaine is used topically to produce numbness. It is more potent that procaine, but may cause swelling and itching. B.9.3. Discuss the advantages and disadvantages of nitrous oxide, ethoxyethane, trichloromethane, cyclopropane and halothane. Nitrous oxide is not very potent, and makes one feel good Trichloromethane is nonflammabe, but leads to liver damages. Narrow safety margin Ethoxyethane alleviates the pain in surgery well, but it is very flammable and nonstable. Cyclopropane is a very potent anaesthetics, however it forms explosive mixtures with air and is very flammable. It also causes vomiting and nausea. Halothane is widely used as it is not flammable and one may recover fast from it. It doesnt irritate the respiratory tract. However, it takes time to become unconscious. It is potentially harmful to the ozone layer as it produces chlorine and bromine free radicals. B.9.4. Calculate the partial pressures of component gases in an anaesthetic mixture The partial pressure ratios of the total pressure equal the molar ratios of different gas molecules. It is important to have enough oxygen in the anaesthetic mixture so that the patient can live. At least 20% oxygen is needed B.10.1 Describe the effects of lysergic acid diethylamide (LSD), mescaline, psilocybin and tetrahydrocannabinol. Psychadelic drugs like these alter the mind and produces a change in thought, perception or mood and induce vivid fantasies. Colors seem more brilliant for the user. There are the effects of the mentioned mind altering drugs: LSD: This is a powerful hallucinogen that strongly magnifies perception and may destroy the sense of judgment. No physical addiction, and not very strong psychological dependence. Mescaline: Color hallucinations which last 12 hours. Psilocybin: Similar to LSD, especially at high doses, but at low doses produces relaxation. Shortlasting; 4 hours THC: Milder drug similar to alcohol. At larger doses, changes in perception occurs sees bright colors and gets sharper hearing. May get extreme anxiety, depression, uneasiness, panic attacks etc. There is no tolerance, but could lead to psychological dependence. B.10.2 Discuss the structural similarities and differences between LSD, mescaline and psilocybin. LSD and psilocybin both have the Indole ring (Heterocyclic amine compound where the nitrogen atom is part of a ring). However, mescaline includes the benzene ring but not the indole ring; it does have a primary amine. Serotonin also has the indole ring. B.10.3 Discuss the arguments for and against the legalization of cannabis. Cannabis offers relief from symptoms from AIDS, cancer and glaucoma. Marijuana may increase the appetite, and relieves nausea. Cannabis helps terminally ill patients to relieve tension and anxiety. Marijuana relieves pressure inside the eyeball for glaucoma patients. However there are many bad sides to it too. Smoking marijuana may lead to lung problems and may suppress the immune system. It might lead to decreased fertility for men and cause brain damage and birth defects. Users may also start using harder drugs too. Users of prohibited drugs need to obtain it from criminal sources and may therefore be forced into crime to support their habit. It damages the society a lot.

Euthanasia :: Free Euthanasia Essay

Euthanasia A considerable portion of society supports euthanasia an instrument of preserving dignity in the terminally ill, bringing peace to the incurable, and closure to their families. Some Americans believe to maintain the democratic values upon which the Unites States stands in balance, they must possess the right to determine the applicable time to end a person’s life.(Chapman 209) The more widely help opinion comes in the form of opposition. The majority strikes out against euthanasia, targeting it as an instrument of the divine, a tool that humans, above democratic values and inalienable rights, dare not employ themselves lest they suffer the wrath of imposing on Almighty God. The human race as a whole must wipe their eyes of their own naà ¯vetà ©. Humans cannot play God. Encroaching on God’s proverbial territory would usurp divine function and interfere with divine plan. (Maguire 132) From Greek words meaning â€Å"good† and â€Å"death†, euthanasia is commonly referred to as mercy killing or physician assisted suicide.(Brody 75) The argument deals with the question of whether licensed physicians have the right to play a role in mercy killing. Indirectly executed and therefore viewed by and large with a lesser face of malcontent, a â€Å"Do Not Resuscitate† order, or DNR, refers to refraining from heroic measures to keep someone alive. In other words, a doctor may withhold treatment to let a person die naturally. Opposition arises in the form of protesters and activists, defrauding and doctor’s right to play God in trauma rooms and on operating tables. Unfortunately, courts and moral theorists ha long accepted the proposition that people have the right to refuse medical treatment they find painful or difficult to bear, even if that refusal means certain death. (Walter 176) A growing concern over medical costs questions family’s ability to make rational decisions as responsible caregivers. The cost of a dose of barbiturates and curare and the few hours in a hospital bed that it takes them to act is minute compared to the massive bills incurred by many patients in the last weeks and months of their lives. Legalizing euthanasia would render substantial monetary resources that could be used by the families or by the healthcare provider for more practical treatments. (Friedman 116) Permitting money to influence human life is overtly immoral, but nevertheless pressures the acceptance of euthanasia. If legalize, the natural evolution of policy and procedure would see growth in the category of patients for whom euthanasia is permitted.

Your Identity

Elvin Roperto Professor Gallers English 101 February 16, 2012 You’re Identity Back in the day, few wondered about their ancestors. The majority of people thought they knew all about their ancestor’s history. Who they we’re, their nationality, and their native language. But today in society many are shocked to find out that their ancestor history or past isn’t true at all because of DNA genealogy. If you thought that your ancestors we’re Puerto Rican and they actually turned out to be Mexican. Would you freak out? Would you have to change your ways?Would you change your traditions? A genealogical DNA test examines the nucleotides in specific locations on a person's DNA to find out where a person’s ancestor comes from. The test results are not meant to have any medical information and the test results do not determine genetic diseases or disorders. They are only intended to give genealogical information. To take a genealogical DNA test all you have to do is a painless cheek-scrapping at your home and mail the sample to a genetic genealogy laboratory for testing.There are a few types a test you can use, but the most popular tests are the Y chromosome test and the mitochondrial DNA test. These tests can determine where your ancestors originated from. I disagree, just because a test tells you where you came from doesn’t mean you have to change anything about yourself. Your Identity isn’t based on your family tree’s past. It’s based on everything we see, feel, hear, taste, smell, and read. Every person you meet, every conversation you have, every event in your life, and the way you interpret all sights, sounds, tastes, smells, actions, and events, shape up who you are as a human being.And nothing in the world should change that, not even your ancestor’s past. On the other hand, can you define yourself as a person without your nationality? How much of who is you are based on your nationality? Can your nationality be a part of your soul? A person's nationality says much about their culture outlook on life, the way they conduct their lives aspirations, and relationships. The way you act, talk, feel can be a result from your nationality. So maybe it’s possible that you an potentially lose yourself because of believing in something that you are not. In general, I can agree with Harmon. Knowing your nationality can make you understand a bit more about your Identity whether in a positive or negative way Overall, DNA genealogy should not change who you are, even though nationality is a big part of your Identity. If you do find out you’re from a different country, you can try to change some of your traditions and cultural views but you’ll still be you. Work Cited http://en. wikipedia. org/wiki/Genealogical_DNA_test

New England and the Chesapeake Colonies Essay

When Jamestown was originally settled, and when the Mayflower landed, the colonists who emerged from the ships had huge plans and tremendous goals for what would come of their own colony. However, although both settled regions were the new homes to a majority of the English, two separate societies formed. In New England, the colonists were religious extremists hoping to form a perfect society, while gold hunters with little or no desire to create a permanent home flocked to the Chesapeake region. The colonists in the north were more concerned with family values than those in the south, whose society suffered from a great lack of women and such a high death rate that family ties were hard to keep. As time went by, the development of slavery and indentured servitude started making an autocracy of rich cash crop farmers in the Chesapeake region, while in New England continued to have a majority of small farmers, along with some fishermen and shipbuilders. The differences between the colonists’ goals, populous, and economy caused New England and the Chesapeake region to form completely separate societies. When the Pilgrims landed in New England, they had no desire other than to create a community which could worship God in the way they saw fit, which was completely different than the desire of the Chesapeake settlers, who wanted gold. The New England colonies were established by religious groups with a strong belief in God and the ability to create a perfect society under Him. They marveled in their religious conviction which allowed them to travel to a completely foreign land, and were positive that, while following their belief system, they could create the perfect mixture of religion, politics, and justice (document A). The amount of effort which the colonists in New England tried to form the perfect society – their â€Å"city upon the hill – went to such an extent that the Articles of Agreement, written in Spr ingfield, 1636, stated that â€Å"our town shall be composed of forty families† (Document D). The New England colonists were so willing to form a perfect community, that they tried to keep track of every little detail of their towns. However, in the Chesapeake region, instead of trying desperately to keep everything in order, the colonists simply wanted to search for gold and return to their home, England. The colonists who went to the Chesapeake region had signed contracts which stated that, for a specific amount of years, they would have to stay in America and search for gold. This, from the start, put a search  for wealth into the southern society. As these contracted colonists searched for gold, they were not allowed to establish true towns or grow crops that would help them survive. Also, the colonists planned on only staying within the area for long enough to find gold, and then to return back to England, causing the desire for community life to decrease. Since they did not build towns and communities as those in New England did, they did not have the same close relationships within neighborhoods grow, as it did for the Puritans. Due to the different goals the colonists had – New England settlers w anting an ideal society, and Chesapeake settlers wanting gold, their growing societies were bound to have differences. As the colonies began to grow, problems with the climate in the Chesapeake region that were not present in New England forced the different regions’ societies to differ all the more. The Chesapeake region, although a great location for defense against enemies, was, basically a swamp. The local area had hot, humid weather that, along with diseases such as malaria, caused the population to have incredibly high death rates. Families never survived long, making remarriages increasingly common and grandparents a foreign idea. To add to the colonists’ discomfort, the amount of women who moved to the area was quite a bit smaller than the amount of men. On a ship heading for Virginia in 1635, only eleven women accompanied sixty-four men (Document C). These highly disproportionate statistics caused family values to decrease; many marriages in which the woman was already pregnant started occurring more commonly and many men went their entire lives without marrying. On quite a different hand, however, the colonists in New England were fortunate enough to live in a friendly climate. Families had many children, often the number of family members reaching into the teens. Along with the fertile area, the colonists were more family oriented, in general, which aided to the ir wish for a model society. More often than in the Chesapeake region, entire families would flock to the New World, making the number of males relatively equal to the number of males (Document B). This allowed for families to be more connected; children in New England were more able to connect with their families, grandparents, and communities than those of the settlers in the Chesapeake region. The terrible climate which caused death to be common in the Chesapeake region, along with the small amount of women, caused its society to differ from that of the colonists in  New England which had large numbers of children and strong family values. As the colonists in the South realized that cash crops, such as tobacco, rice, and indigo grew incredibly well in their climate, they also realized the need for large plantations, while colonists in the North depended on fishing, shipbuilding, and small farms to survive. After a bit of experimenting, the southern colonists realized that several crops could grow exceptionally well in their swampy climate that could bring them a rather large profit. However, these crops took an extremely high amount of effort that many farmers were not willing to give. So, instead, they â€Å"hired† indentured servants to do the work for them. While these farmers received labor for several years, they also received a land claim which was given to anyone who paid for a voyage to the New World, whether he was the actual person to take the trip or not. While this brought many new people over as indentured servants, the original farmers gained more land, which allowed them to make more money. However, while the original farmers were becoming quite rich, the indentured servants, once freed, gained barely anything, and no land rights which allowed them to start their own farms. The poor ex-servants became outraged at their inability to find any sort of jobs other than working for their former masters. The southern society was quickly becoming an autocracy, since the small amount of wealthy plantation owners ruled over the poor small farmers and indentured servants. However, the ex-servants’ unrest soon became solid with Bacon’s rebellion. Suddenly, the plantation owners noticed the need for a work-force, which led to a large increase of slave imports. The most cruel and heartless business operation, which lead to an even greater separation between rich and poor in the southern autocracy, had begun. However, in New England, where large plantations were nearly impossible due to the incredible rocky terrain, fishing was discovered. The colonists discovered a large abundance of cod near their colony, which led to the creation of fishing industries, a business that turned into a very important part of New England life. Along with fishing, the fores ts surrounding the New England colonies allowed the colonists to start shipbuilding companies, which also added to the economy. However, although the fishing and shipbuilding were important to the New England economy, a majority of the people continued to grow family-sized farms. While the Chesapeake region had large plantations which made town  meetings and get-togethers nearly impossible, the sea-oriented businesses of the New England colonies allowed the towns to be more extroverted. Although both regions of colonies in the New World had originated from the same small island, almost immediately the resulting societies differed substantially. Since one group of colonists fled from their home country to avoid religious persecution, and another group fled in order to avoid an economic depression, one society started with a stronger religious bases than the other. Since one group began with families and strong values while another group began with a large group of men and few women, one society had stronger family ties while the other one worried about extinction. Since one group established an autocracy bas ed off of large plantations, and the other off of small fishing and farming communities, one society had a larger gap between poor and rich than the other. The differences between family values, population, economy, and religion between the Chesapeake region and New England caused the two regions to form extremely separate societies.

Japanese Garden essays

Japanese Garden essays -A contribution of building ethnology to Swiss Federal Institute of Technology (ETH), Zurich Throughout long periods of time and in many cultures the human spirit has been preoccupied with trees. Evidence of this is to be found in the many representations, pictorial and textual, which tell us of sacred trees, trees of life and light, cosmic or world trees, the Tree of Knowledge in the Garden of Eden, trees of everlasting life, of eternal youth and so on. The wide extent of symbolism centered on the tree and its long history as the focal point of ideal worlds is also reflected in the many studies and investigations on this subject. The abundance of studies is due not only to the great extent of mans spiritual relationship to trees, but also to modern mans attraction to the rich symbolism surrounding the tree. The fantastic associations with which primitive cultures have invested something that now appears to us as a natural object are indicative of a way of thinking that, in its stronger imaginative power, completely overshadows our own And yet, are we right in our ideas about this earlier power of imagination? Has symbolic thinking of this kind really sprung exclusively from the spirit As suggested by the German word Einbildung ( inimagination ), might it not have been sparked off by structures of the world of things Does symbolism only seem fantastic because it derives from events of cultural history which are now lost in the depths of time In other words, could it be that what we regard as specifically spiritual in mans relation to the tree is actually traceable to lost culture ...

READ THIS Before You Enroll in KDP Select!

READ THIS Before You Enroll in KDP Select! READ THIS Before You Enroll in KDP Select! We get it: writing a book requires a lot of your time, effort, and money. Taking a book from inception to completion is intense work, and by the time you’re ready to publish you might find yourself referring to your manuscript as â€Å"my baby.†Of all the big decisions you have to make in your journey as a self-publishing author, one of the biggest is whether or not to enroll your ebook in Amazon's KDP Select: a program which offers authors bonus incentives in exchange for granting Amazon exclusivity.But going exclusive is a big deal. Are you sure you want to let Amazon put a ring on it before your book has had a chance to test out the other options? Is Amazon's Select program the right choice for you? That’s what we’ll answer in this post, covering all the points in the table of contents (to your left).Let’s get started with the basics. The great "KDP Select or not" debate: where do you stand? What is Kindle Direct Publishing?Kindle Direct Publishing (KDP) is Amazon’s ebook publishing unit, which allows authors to sell their books directly to Amazon’s readers. The Kindle and KDP were launched concurrently in 2007, laying the groundwork for Amazon’s ebook empire which now holds more than 80% of the market in the United States and United Kingdom.Success stories from authors self-publishing through Amazon KDP began to roll out around 2011, with the popularity of Andy Weir’s The Martian and Wool by Hugh Howey. But they’re not without company: in 2018, Jeff Bezos revealed that over 1,000 authors had earned over $100,000 through Kindle Direct Publishing.While numbers like these are not the norm for the average writer, KDP has become the heavily preferred route for self-publishing authors - many of whom also decide to enroll in Amazon's Select program. Speaking of which...What is KDP Select?KDP Select is a program available to all authors willi ng to grant Amazon exclusive rights to sell their ebook through the Kindle store only.By agreeing not to sell the digital file of their book through any other retailers, authors are given access to a variety of promotional tools - the most significant of which is Kindle Unlimited -   and the opportunity to earn higher royalties (in some cases, more on that later).The KDP Select program lasts 90 days, after which authors can either choose to opt out of the program, or auto-renew for another 90-day commitment.While digital copies of the book must only be sold through Amazon:A 10% sample of the book can be made available outside of the Kindle Store;Print (or any other non-digital) versions can be distributed elsewhere; andCopies of the book can be emailed to reviewers for editing purposes.So, a higher percentage of sales and additional book marketing tools: sounds pretty good, right? Why would an indie author not want those things? Well, the question of whether to grant Amazon exclu sivity or to â€Å"go wide† is a constant talking point amongst self-publishing authors, as both options come with their own sets of pros and cons. The biggest and most important pro of enrolling in Amazon's Select program is undoubtedly the access to Kindle Unlimited. So before we get too far into discussing pros and cons, let's quickly cover exactly what Kindle Unlimited is.What is Kindle Unlimited?Kindle Unlimited (KU) is an â€Å"all-you-can-read† service that allows subscribers to read as many ebooks as they’d like for $9.99 a month (if you’re thinking â€Å"Netflix for books,† you’re on the money). When authors enroll in Amazon's Select program, their books are automatically made available to readers on KU. (For a comprehensive guide to KU, check out our post right here.) With all of this in mind, remember that whether you decide to go with KDP Select or open publishing, you’ll get out of it what you put into it. If you use KDP Select’s Countdown Deals or Free Promotions but don’t spend any time advertising your promotions, they won’t lead to much exposure - the whole point of these tools.If you decide to forgo the increased visibility that can come with Kindle Unlimited, make sure you spend time getting acquainted with the aggregators out there or developing various book marketing strategies - or else the benefits of going wide will end up falling flat.We hope this post has been helpful in considering the pros and cons of KDP Select vs. going wide, and that you feel more confident in leveraging the route you choose for your book’s success.Are you enrolled in KDP Select or considering it? Let us know your thoughts and questions in the comments below!

Spiritual and Cultural Considerations in Primary Care Assignment

Spiritual and Cultural Considerations in Primary Care - Assignment Example Similar with the Asian American culture, Hispanic American also believe that health can be attained by maintaining balance between the hot and cold and the wet and dry forces. Illness results when God punished Hispanic Americans for their sin, when feeling of susto (fright) occur, when someone throws a mal ojo (evil eye), and envidia (envy)(De Laune, 2006, p. 394). Hispanic Americans used Spanish or Portuguese and other dialects in communication process. They are verbally expressive and used dramatic body language to express emotions and pain. However, Hispanic Americans view direct confrontation and expression of negative feelings as disrespectful. When communicating with a Hispanic American, one can observe the comfort in close proximity, overly tactile communication such as frequent handshakes and enbrace, and the value Hispanic Americans have for the presence of others. Hispanic Americans value modesty and politeness in speaking and are presently oriented. However, time for Hispa nic American is flexible. The role of the family in the primary care might be used in dealing with Hispanic Americans as they prioritize first the need of the families before the individual needs. Nuclear family is the basic unit but highly regarded extended family. Gender roles are also evident in the Hispanic American culture and man performs the role of decision maker and breadwinner while the woman is the home maker and care taker. Review of Literature Healthcare Concerns and Beliefs Health care concerns and beliefs of many Hispanics have affected the predisposing diseases of their race and access to the use of health services. Hispanic diet, lack of health insurance, transportation, culture, and linguistic are some of the identified concerns of most researchers among Hispanics that needs to be addressed. Hispanic dietary preferences differ from other culture. Existing research suggests that Hispanic diet has greater percentage of carbohydrates, protein, and fiber, and lower percentage of total and satura ted fat (Loria, Bush, Carroll, Looker, McDowell, Johnson, &Sempos, 1995, n.p.).Thus, Hispanics are more apt to meet the cholesterol education program. However, majority of the Hispanics suffer from obesity which is one of the most important health problems they are facing today. Aside from dietary preferences, Hispanics also lack sufficient access to health services particularly because of financial, structural, and personal barriers. Lack of health insurance and low income among Hispanics constitute the financial barriers. Structural barriers include proximity and transportation to the health providers and personal barriers include cultural and linguistic factors. In addition, Hispanics are less likely to consult a primary care’s advice primarily because Hispanics believe that having a disease is a punishment from God. For example, a child suddenly has fever after the parents brought the child to the park. Following Hispanic culture, this child was thrown a mal ojo (evil eye ) by a stranger. Hispanics are known for being religious and spiritual-driven. Hispanics belief on God and evil forces are